同济大学化学科学与工程学院

姚天明

作者:时间:2016-02-20点击数:

姚天明

姚天明 教授 博士生导师

联系电话:021-65983292

Email:tmyao@tongji.edu.cn

专业方向:无机化学

办公室:化学馆 323室

研究方向:生物无机化学,化学生物学

个人介绍

【简介】

教授,博士生导师。1994年毕业于南京大学化学系,获博士学位。1996年同济大学化学系副教授,无机化学教研室主任。1997年被评为上海市优秀高校青年教师,同济大学优秀青年教师。2000年入选首批教育部高校骨干教师资助计划。2002年被评为同济大学教授,2003年博士生导师。2006~2009年任同济大学化学系副主任,化学系本科教学指导委员会主任。1999年赴台湾中山大学访问研究,博士后研究员,从事有机合成无水无氧操作。2001~2003年获日本学术振兴会(JSPS)资助赴日本大阪药科大学从事关于tau蛋白结构及变化与AD之间关系的研究,外国人特别研究员。先后主持国家自然科学基金面上项目(5项)、上海市科委重点科技攻关项目(1项)。还获得:教育部留学回国人员基金、教育部国家重点实验室高级访问学者专项、南京大学配位化学重点实验室开放基金、中科院上海有机化学所生命有机国家重点实验室开放基金、中山大学教育部生物无机开放实验室基金等多项基金资助。从事tau蛋白与核酸化学生物学方面的研究。期间曾获宝钢优秀教师奖、李国豪奖、同济大学教学名师奖、同济大学教学成果一等奖等。

【研究兴趣】

(1)基于核酸适配体机制、抗体抗原免疫机制,结合量子点、石墨烯等纳米材料,设计构建可应用于临床诊断、食品环境检测等方面的新型荧光传感器。(2)提出双端识别发卡型结构的设计理念,筛选修饰天然有机小分子,研发神经元纤维性缠结相关蛋白Tau自聚集抑制剂和先导化合物,探索阿尔茨海默病药物设计新思路。(3)通过探索疾病相关蛋白质、核酸的结构异变,及其与金属配合物相互作用规律,揭示阿尔茨海默症、癌症等疾病的分子机制。

【主持科研项目】

• 国家自然科学基金(81871730):同步分析多生物标记物的逻辑门传感器构建与AD诊断探索

• 国家自然科学基金(21472139):双端识别发卡型Tau蛋白自聚集抑制剂的分子设计与构建

• 国家自然科学基金(81171646):痕量Tau蛋白标记检出方案设计及其相关基础过程研究

• 国家自然科学基金(20871094):若干神经毒性金属与tau蛋白微管结合域的配位及其对构象的诱变作用

• 国家自然科学基金(20472065):Tau蛋白异常聚集的分子机制与Alzheimer病新药设计的化学基础

【近年代表性论文】

• Ru-Ru Gao, Tian-Ming Yao*, Xiao-Yan Lv, Yan-Yan Zhu, Yi-Wei Zhang, Shuo Shi*, Integration of G-quadruplex and DNA-templated Ag-NCs for nanoriththmetic information processing, Chemical Science, 2017,8,4211-4222.

• Ru-Ru Gao, Shuo Shi*, Yu-Jie Li, Maierhaba Wumaier, Xiao-Chun Hu, Tian-Ming Yao*, Coordination polymer nanoparticles from nucleotide and lanthanide ions as a versitile platform for color-tunable luminescence and integrating Boolean logic operations, Nanoscale, 2017,9, 9589-9597.

• Ao Huang, Weiwei Li, Shuo Shi*, Tianming Yao*, Quantitative Fluorescent Quenching on Antibody-conjugated Graphene Oxide as a Platform for protein sensing, Scientific Reports, 2017,7,40772.

• Ruru Gao, Shuo Shi*, Ying Zhu, Hailiang Huang, Tianming Yao*, A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions,Chemical Science,2016,7, 1853-1861.

• Ying Zhu, Xiaochun Hu, Shuo Shi*, Ruru Gao, Hailiang Huang, Yanyan Zhu, Xiaoyan Lv, Tianming Yao*, Ultrasensitive and universal fluorescent aptasensor for the detection of biomolecules (ATP,adenosine and thrombin)based on DNA/Ag nanoclusters,Biosensors and Bioelectronics,2016,79, 205-212.

• Hailiang Huang, Shuo Shi*, Xing Gao, Ruru Gao, Ying Zhu, Xuewen Wu, Ruimin Zan, Tianming Yao*, A universall abel-free fluorescent aptasensor, based on Ru complex and quantum dots for adenosine, dopamine and 17β-estradiol detection,Biosensors and Bioelectronics,2016,79, 198-204

• Juanjuan Li, Xiaochun Hu, Shuo Shi*, Yiwei Zhang, Tianming Yao*, Three label-free thrombin aptasensors based on aptamers and [Ru(bpy)2(o-mopip)]2+,Journal of Materials Chemistry B,2016,4, 1361-1367.

• Hailiang Huang, Shuo Shi*, Xuyue Zhen, Tianming Yao*, Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signa lamplification,Biosensors and Bioelectronics,2015,71, 439-444.

• Shuo Shi*, Jinhong Xu, Xing Gao, Hailiang Huang, Tianming Yao*, Binding Behaviors for Different Types of DNA G-Quadruplexes:,Enantiomers of [Ru(bpy)2(L)]2+(L=dppz, dppz-idzo),CHEMISTRY A European Journal,2015,21, 11435-11445.

• Xuyue Zhen, Tianming Yao*, Ying Zhu, Shuo Shi*, Cu2+modulated silver nanoclusters as an on–off–on fluorescence probe for the selective detection of L-histidine,Biosensors and Bioelectronics,2015,66, 103-108.

• Linlin Wang, Tianming Yao*, Shuo Shi*, Yanlin Cao, Wenliang Sun, A label-free fluorescent probe for Hg 2+ and biothiols based on graphene oxide and Ru-complex,Scientific Reports, 2014,4, 5320.

• Yanlin Cao, Shuo Shi*, Linlin Wang, Junliang Yao, Tianming Yao*, Ultrasensitive fluorescence detection of heparin based on quantum dots and a functional ruthenium polypyridyl complex,Biosensors and Bioelectronics, 2014,55,174-179.

• Xiaohui Lu, Shuo Shi*, Junliang Yao, Xing Gao, Hailiang Huang, Tianming Yao*, Two structurally analogous ruthenium complexes as naked-eye and reversible molecular “light switch” for G-quadruplex DNA,J.Inorg.Biochem.,2014,140,64-71.

• Junliang Yao, Xing Gao, Wenliang Sun, Tianming Yao*, Shuo Shi* and Liangnian Ji, Molecular hairpin: a possible model for inhibition of tau aggregation by tannic acid,Biochemistry-US, 2013,52, 1893-1902.

• Jun-Liang Yao, Xing Gao, Wenliang Sun, Shuo Shi*, Tian-Ming Yao*, [Ru(bpy)2dppz-idzo]2+: A colorimetric molecular “light switch” and powerful stabilizer for G-quadruplex DNA,Dalton Trans., 2013,42, 5661.

• Yao Junliang, Gao Xing, Sun Wenliang, Fan Xuezhong, Shi Shuo*, Yao Tianming*, A Naked-Eye On–Off–On Molecular “Light Switch” Based on a Reversible “Conformational Switch” of G-Quadruplex DNA,Inorg.Chem., 2012,51, 12591.

• Ting-Ting Cheng, Jun-Liang Yao, Xing Gao, Wenliang Sun, Shuo Shi* and Tian-Ming Yao*, A new fluorescence “switch on” assay for heparin detection by using a functional ruthenium polypyridyl complex,Analyst, 2013,138, 3483.

• Wenliang Sun, Junliang Yao, Tianming Yao* and Shuo Shi*, Label-free fluorescent DNA sensor for the detection of silver ions based on molecular light switch Ru complex and unmodified quantum dots,Analyst, 2013,138, 421.

• Shuo Shi*, Hai-Liang Huang , Xing Gao, Jun-Liang Yao,Chun-Yan Lv, Juan Zhao, Wen-Liang Sun, Tian-Ming Yao*, Liang-Nian Ji,A comparative study of the interaction of two structurally analogous ruthenium complexes with human telomeric G-quadruplex DNA,J.Inorg. Biochem.,2013,121, 19.

• Dan-Jing Yang, Shuo Shi*, Tian-Ming Yao*, Liang-Nian Ji, Cooperative folding of tau peptide by coordination of group IIB metal cations during heparin-induced aggregation,Biometals,2012,25, 361-372.

• Wenliang Sun, Tianming Yao* and Shuo Shi*, A molecular light switch Ru complex and quantum dots for the label-free, aptamer-based detection of thrombin,Analyst, 2012,137, 1550–1552.

• Shuo Shi,* Juan Zhao, Xing Gao, Chunyan Lv, Li Yang, Jian Hao, Hailiang Huang, Junliang Yao, Wenliang Sun, Tianming Yao* and Liangnian Ji, Molecular “light switch” for G-quadruplex DNA: cycling the switch on and off,Dalton Trans., 2012,41, 5789-5793.

• Dan-Jing Yang, Shuo Shi, Tian-Ming Yao*, and Liang-Nian Ji, The Impacts of Hg(II) Tightly Binding on the Alzheimer’s Tau Construct R3: Misfolding and Aggregation, Bull.Chem. Soc. Jpn., 2011,84, 1362-1367.

• Wenliang Sun, Shuo Shi and Tianming Yao*, Graphene oxide–Ru complex for label-free assay of DNA sequence and potassium ions via fluorescence resonance energy transfer,Anal. Methods(RSC),2011,3, 2472.

• Dan-Jing Yang, Shuo Shi, Leng-Feng Zheng, Tian-Ming Yao*, and Liang-Nian Ji , Mercury(II) Promotes the in vitro Aggregation of Tau Fragment Corresponding to the Second Repeat of Microtubule-Binding Domain: Coordination and Conformational Transition, Biopolymers, 2010,931100.

• Lin-Jie Han, Shuo Shi, Leng-Feng Zheng, Dan-Jing Yang,Tian-Ming Yao*, Liang-Nian Ji, Flavonoids Inhibit Heparin-Induced Aggregation of the Third Repeat (R3) of MBD of Alzheimer's Tau Protein,Bull.Chem. Soc. Jpn., 2010,83, 911.

• Shuo Shi*, Juan Zhao, Xiaoting Geng, Tianming Yao*, Hailiang Huang, Tianlin Liu, Lengfeng Zheng, Zonghui Li, Danjing Yang, Liangnian Ji, Molecular “light switch” for G-quadruplexes and i-motif of human telomeric DNA: [Ru(phen)2(dppz)]2+,Dalton Trans., 2010,39, 2490.

• Shuo Shi *, Xiaoting Geng, Juan. Zhao, Tianming Yao*, Chaoran Wang, Danjing Yang, Lengfeng Zheng, Liangnian Ji, Interaction of [Ru(bpy)2(dppz)]2+with human telomeric DNA: preferential binding to G-quadruplexes over i-motif,Biochimie, 2010,92, 370.

• Shuo Shi*, Tian Xie, Tian-Ming Yao*, Chao-Ran Wang, Xiao-Ting Geng, Dan-Jing Yang, Lin-Jie Han, Liang-Nian Ji, Synthesis, characterization, DNA-binding and DNA- photocleavage studies of [Ru(bpy)2(pmip)]2+and [Ru(phen)2(pmip)]2+(pmip = 2-(2′-pyrimidyl)imidazo[4,5-f][1,10] phenanthroline,Polyhedron, 2009,18, 1355.

• Ling-Feng Jiang, Tian-Ming Yao*, Zhi-Liang Zhu, Liang-Nian Ji, “Impacts of Cd(II) on the conformation and self-aggregation of Alzheimer’s tau fragment corresponding to the third repeat of microtubule-binding domain” Biochimica et Biophysica Acta,2007,1774:1414-1421.

• Koji Tomoo, Tian-Ming Yao*, Toshimasa Ishida, et al. " Possible Role of Each Repeat Structure of the Microtubule-Binding Domain of the Tau Protein in In Vitro Aggregation",Journal of Biochemistry, 2005,138: 413-423.

• Katsuhiko Minoura, Tian-Ming Yao*, Koji Tomoo, Toshimasa Ishida, et al. "Different associational and conformational behaviors between the second and third repeat fragments in tau microtubule-binding domain",European Journal of Biochemistry, 2004,271: 545-552.

• Shuko Hiraoka, Tian-Ming Yao, Koji Tomoo, Toshimasa Ishida, et al, "Conformational Transition State Is Responsible for Assembly of Microtuble-binding Domain of Tau Protein",Biochem Biophys Res Commun. 2004,315(3):659-663.

• Tian-Ming Yao*,Koji Tomoo, Toshimasa Ishida, et al. "Aggregation Analysis of the Microtubule Binding Domain in Tau Protein by Spectroscopic Methods",Journal of Biochemistry, 2003,134: 91-99.

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