Introduction

I Research Area

1. Multifunctional nanogel composites for responsive biological imaging and drug delivery

2. Synthesis of mesoporous silica-based nanomaterials for biomedical diagnosis and therapy

II Honors & Awards

III Academic Achievements

There are 29 SCI papers published on Adv. Mater., ACS Nano, Biomaterials, Small and so on, with more than 400 SCI citations. About 6 scientific projects, including the National Natural Science Foundation of China and Shanghai Chenguang program have been developed, and series of research collaborations with the Tenth People's Hospital, Fudan University Cancer Hospital, East China University of Science and Technology have been established.

Projects:

1. Hybrid nanogel system for responsive ultrasound/enhanced MR imaging guided high-intensity focused ultrasound therapy（51402215）National Natural Science Foundation of China 2015.01-2017.12

2.Construction of multifunctional mesoporous silica system for arginine depletion therapy/chemotherapy (15CG16) Shanghai Chenguang Project 2016.01-2018.12

Publication:

1.   Xia Wang, Qigang Wang,* Enzyme-Laden Bioactive Hydrogel for Biocatalytic Monitoring and Regulation, Acc. Chem. Res. 2021, 54, 1274−1287.

2.   Xianmeng Xia , Xia Wang,* Xiaoke Han , Meiyuan Qi , Ya Gao , Jiangnan Liao , Xingyue He , Kai Pan , Qian Cheng, Qigang Wang,* Construction of self-assembled nanogel as mulitenzyme mimics for bioresponsive tandem-catalysis imaging, Science China Materials, DOI:10.1007/s40843-021-1697-x, 2021.

3.   Qing Wu, Zhigang He, Xia Wang,* Qi Zhang, Qingcong Wei, Sunqiang Ma, Cheng Ma, Jiyu Li,* Qigang Wang,* Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy, Nature Communications, 10, 240, 2019.

4.   Xia Wang, Shuangshuang Chen, Dongbei Wu, Qing Wu, Qingcong Wei, Bin He,* Qinghua Lu,* Qigang Wang,* Oxidoreductase-Initiated Radical Polymerizations to Design Hydrogels and Micro/Nanogels: Mechanism, Molding, and Applications, Advanced Materials, 1705668, 2018

5.   Xia Wang, Xiao Yu, Xiaoshan Wang, Meiyuan Qi, Jing Pan, and Qigang Wang,* One step Nanosurface Self-assembly of D-peptides Renders Bubble-Free Ultrasound Theranostics, Nano Letters, 19 (4), 2251-2258, 2019.

6.   Xia, Wang#; Li, Qiao#; Xiao, Yu; Xiaoshan, Wang; Lixin, Jiang*; Qigang, Wang*; Controllable Formation of Ternary Inorganic-Supramolecular-Polymeric Hydrogels by Amidation-Fueled Self-assembly and Enzymatic Post-cross-linking for Ultrasound Theranostic, ACS Biomaterials-Science & Engineering, 2019, 5(11): 5888-5896

7.   Meiyuan Qi, Hui Pan, Hongdou Shen, Xianmeng Xia, Chu Wu, Xiaoke Han, Xingyue He, Wei Tong, Xia Wang* and Qigang Wang*, Multienzyme-Mimic Nanogels Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging, Angewandte Chemie International Edition, 2020, 2020, 59, 11748–11753.

8.   Qi Zhang, Yanan Lv, Mingyu Liu, Xia Wang,* Yongli Mi* and Qigang Wang,* Nanoinitiator for enzymatic anaerobic polymerization and graft enhancement of gelatin–PAAM hydrogel, Journal of Materials Chemistry B, 6, 1402-1409, 2018.

9.   Qiao Li, Gao Yawei, Wei Qingcong, Hu Wen, Wu Lei, Li Pei, Zhu Rongrong, Wang Xia,* Wang Qigang,* Laccase-mediated formation of mesoporous silica nanoparticle based redox stimuli-responsive hybrid nanogels as a multifunctional nanotheranostic agent, Nanoscale, 8(39), 17241-17249, 2016.

10. Xia Wang, Dechao Niu, Pei Li, Qing Wu, Xiaowan Bo, Boji Liu, Song Bao, Teng Su,  Huixiong Xu,* and Qigang Wang,* Dual-Enzyme-Loaded Multifunctional Hybrid Nanogel System for Pathological Responsive Ultrasound Imaging and T2-Weighted Magnetic Resonance Imaging, ACS Nano, 9(6), 5646–5656, 2015.

11. Xia Wang, Hangrong Chen*, Yu Chen, Ming Ma, Kun Zhang, Faqi Li, Yuanyi Zheng, Deping Zeng, Qi Wang and Jianlin Shi*, Perfluorohexane-encapsulated mesoporous silica nanocapsules as enhancement agents for highly efficient high intensity focused ultrasound (HIFU), Advanced Materials, 6, 785-791, 2012.

12. Xia Wang, Dechao Niu, Qing Wu, Song Bao, Teng Su, Xiaohang Liu, Shengjian Zhang, and Qigang Wang*. Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents. Biomaterials, 53: 349-357, 2015.

13. Xia Wang, Hangrong Chen*, Yuanyi Zheng, Ming Ma, Yu Chen, Kun Zhang, Deping Zen, Jianlin Shi*, Au-nanoparticle coated mesoporous silica nanocapsule-based multifunctional platform for ultrasound mediated imaging, cytoclasis and tumor ablation, Biomaterials, 34, 2057-2068, 2013.

14. Xia Wang, Hangrong Chen*, Kun Zhang, Ming Ma, Faqi Li, Shuguang Zheng,Yu Chen, Lixin Jiang Huixiong Xu and Jianlin Shi*, An intelligent nanotheranostic agent for targeting, redox-responsive ultrasound imaging and the imaging-guided HIFU synergistic therapy, Small, 10(7):1403-1411, 2014.