石硕	教授，博士/博导	研究方向	化学生物学
	E-mail	shishuo@tongji.edu.cn
	联系方式	上海市四平路1239号同济大学化学馆548室
	个人主页	https://www.x-mol.com/groups/shishuo

个人介绍

石硕，同济大学化学科学与工程学院教授，博士生导师，普通化学教研室主任，普通化学课程负责人，毕业于中山大学 (2007年)，获化学生物学专业理学博士学位（导师：中国科学院院士，计亮年教授），美国加州理工学院访问学者 (2012-2013年，导师：美国国家科学院院士：Professor J. K. Barton)。2007年进入同济大学工作至今，历任讲师 (2007)、副教授 (2010)，教授 (2015), 荣获上海市科技进步奖，上海医学科技奖青年奖，同济大学青年岗位能手，同济大学优秀青年教师，同济大学骨干教师等荣誉。

一、研究兴趣

(1) 新药研发及癌症的多模式治疗；

(2) 生物传感器构筑及疾病基因诊断；

(3) DNA分子器件设计。

二、学术成果

目前以第一作者或通讯作者在Advanced Materials, Coordination Chemistry Reviews, Materials Horizons, Chemical Science, Small, Biosensors and Bioelectronics, Journal of Controlled Release, ACS Materials Letters, Advanced Healthcare Materials, ACS Applied Materials & Interfaces, Nano Research, Acta Biomaterialia, Journal of Nanobiotechnology, Materials Today Bio, Chemical Communications, Chemistry. A European. Journal, Cancers, Nanoscale, Advanced Therapeutics, Communications Biology, Inorganic Chemistry Frontiers, Inorganic Chemistry, Journal of Materials Chemistry. B, Journal of Physical Chemistry B, Biochemistry, Dalton Trans等期刊发表SCI收录论文100余篇(IF＞10, ＞20篇)，h因子31，论文被引用3000余次，多篇研究论文被评为该领域的TOP 10论文，并有10余项已授权发明专利。

担任Advanced Materials, Advanced Functional Materials, Chemical Science, Small, Chem. Comm, Chem. Eur. J., Biosensors and Bioelectronics, ACS Appl. Mater. Interfaces, Journal of Materials Chemistry A/B, Inorganic Chemistry, Biochemistry, Methods, Dalton Trans, Physical Chemistry Chemical Physics, Analyst, Metallomics, Molecular BioSystems, Biochimie, Journal of Inorganic Biochemistry, European Journal of Medicinal Chemistry, DNA and Cell Biology等50余种期刊审稿专家。

担任 Cancers, American Journal of Biosensor & Bioelectronics, Journal of Biochemistry and Molecular Biology Research, Telomere and Telomerase 编委 (Editorial Board Member).

三、主持科研项目（仅列10项）

(1) 可调控免疫应答的新型奥沙利铂前药分子构建及其增敏铁死亡研究 (国家自然科学基金)

(2) 基于DNA构象变化的逻辑门网络化构筑及其分子密码应用 (国家自然科学基金)

(3) G-四链体稳定与解旋的分子构筑及肌萎缩侧索硬化症(ALS)的基因疗法初探 (国家自然科学基金)

(4) 靶向癌基因启动子区G-四链体的钌配合物的合成及抗肿瘤机制研究(国家自然科学基金)

(5) 手性钌铱双核配合物对G-quadruplex和I-motif的选择性识别研究 (国家自然科学基金)

(6) 重编程有氧呼吸的新型奥沙利铂前药递送系统的构建及其增敏铜死亡研究 (上海市自然科学基金)

(7) 新型药物制剂递释系统的设计及其多通路协同抗肿瘤研究 (同济大学自主原创重点项目)

(8) DNA生物传感器的构建与若干疾病的分子诊断研究 (中央高校基本科研业务费)

(9) 单双核钌配合物与DNA的键合性质研究 (同济大学优秀青年人才)

(10) 小分子药物设计合成及抗肿瘤活性测试研究 (横向项目)

四、教学

主要承担 “普通化学”、“化学生物学”、“生物无机化学”、“普化实验”、“医用化学实验”(留学生，英文授课) 的教学任务。主持教改项目5项，曾荣获同济大学青年教师讲课竞赛最佳教学设计奖；同济大学青年教师讲课竞赛最佳教学内容、方法、手段奖；首届同济大学教师教学创新大赛二等奖，教学活动创新奖；同济大学本科生学科竞赛优秀指导老师，同济大学/巴斯夫优秀科技论文指导老师奖等荣誉。

五、代表性论著（时间倒序）

n 70. Chunhui Wang, Xinda Yang, Chunyan Dong, Keke Chai, Juan Ruan and Shuo Shi*, Cu-related agents for cancer therapies, Coordination Chemistry Reviews, 2023, 487, 215156. (IF=24.833)

n 69. Yiming Rao‡, Ting Fan‡, Lulu Zhou, Kang Fang, Yanting Sun, Xiaochun Hu, Anqi Wang, Ruihao Li, Zhounan Zhu, Chunyan Dong*, Shuo Shi*, A positive self-sufficient H₂O₂ and acidity enhancement circulation for boosting chemodynamic-photothermal-starvation synergistic therapy, Journal of Controlled Release, 2023, 354, 701-712. (IF = 11.467)

n 68. Mohamed Nabeel Mattath, Debasis Ghosh, Chunyan Dong, Thimmaiah Govindaraju*, and Shuo Shi*, Mercury mediated DNA-Au/Ag nanoclusters ensemble to generate gray code encoder for biocomputing, Materials Horizons, 2022, 9, 2109-2114. Outside Front Cover (IF = 15.717)

n 67. Xiaochun Hu†, Ruihao Li†, Wenjing Wu, Kang Fang, Zhounan Zhu, Yixuan Wang, Lulu Zhou, Mengyao, Chen, Chunyan Dong*, and Shuo Shi*, A Fe(III)-porphyrin-oxaliplatin(IV) nanoplatform for enhanced ferroptosis and combined therapy, Journal of Controlled Release, 2022, 348, 660–671. (IF = 11.467)  

n 66. Mengyao Chen†, Jingxian Yang†, Chunyan Dong* and Shuo Shi*, A dual-responsive and ROS-augmented nanoplatform for chemo/photodynamic/chemodynamic combination therapy of triple negative breast cancer, ACS Appl. Mater. Interfaces 2022, 14, 1, 57–68. (IF =10.383)

n 65. Mengyao Chen, Chunyan Dong* and Shuo Shi*, An overview of recent advancement on manganese-based nanostructures and their application for ROS-mediated tumor therapy, Acs Materials Letters, 2022, 4, 2415-2433. (IF=11.17)

n 64. Ruihao Li†, Xiaochun Hu†, Fangjian Shang, Wenjing Wu, Haijun Zhang, Yixuan Wang, Jiawei Pan, Shuo Shi* and Chunyan Dong*, Treatment of triple negative breast cancer by near infrared light triggered mild temperature photothermal therapy combined with oxygen-independent cytotoxic free radicals, Acta Biomaterialia, 2022, 218–229.  (IF = 10.633)

n 63. Xiaochun Hu†, Hui Li†, Ruihao Li, Sufeng Qiang, Mengyao Chen, Shuo Shi* and Chunyan Dong*, A phase-change mediated intelligent nanoplatform for chemo/photothermal/photodynamic therapy of cancer, Advanced Healthcare Materials, 2022, 2202245. (IF=11.092)

n 62. Yanting Sun†, Kang Fang†, Xiaochun Hu, Jingxian Yang, Zhengyang Jiang, Lei Feng, Ruihao Li, Yiming Rao, Shuo Shi* and Chunyan Dong* , NIR-light-controlled G-quadruplex hydrogel for synergistically enhancing photodynamic therapy via sustained delivery of metformin and catalase-like activity in breast cancer, Materials Today Bio, 2022, 16 100375. (IF = 10.761)

n 61. Lei Feng†, Mengyao Chen†, Ruihao Li, Lulu Zhou, Chunhui Wang, Pingting Ye, Xiaochun Hu, Jingxian Yang, Yanting Sun, Zhounan Zhu, Keke Chai, Kang Fang, Shuo Shi* and Chunyan Dong*, Biodegradable oxygen-producing manganese-chelated metal organic frameworks for tumor-targeted synergistic chemo/photothermal/ photodynamic therapy, Acta Biomaterialia, 2022, 138, 463–477. (IF = 10.633)

n 60. Sufeng Qiang†, Xiaochun Hu†, Ruihao Li, Wenjing Wu, Kang Fang, Hui Li, Yanting Sun, Shujing Liang, Wenrong Zhao, Mengjie Wang, Yun Lin, Shuo Shi*, and Chunyan Dong*, CuS nanoparticles-loaded and cisplatin prodrug conjugated Fe(III)-MOFs for MRI-guided combination of chemotherapy and NIR-II photothermal, ACS Appl. Mater. Interfaces, 2022, 14, 32, 36503–36514. (IF =10.383)

n 59. Pinting Ye, Lei Feng, Shuo Shi*, Chunyan Dong*, The mechanisms of lncRNA-mediated multidrug resistance and the clinical application prospects of lncRNAs in breast cancer, Cancers, 2022, 14(9), 2101. (IF = 6.575)

n 58. Jie Liu†, Xiaochun Hu†, Lei Feng, Yun Lin, Shujing Liang, Zhounan Zhu, Shuo Shi* and Chunyan Dong*, Carbonic anhydrase IX‑targeted H‑APBC nanosystem combined with phototherapy facilitates the efficacy of PI3K/mTOR inhibitor and resists HIF‑1α‑dependent tumor hypoxia adaptation, Journal of Nanobiotechnology, 2022, 20, 187. (IF = 9.429)

n 57. Lulu Zhou^#, Jinjin Chen^#, Ruihao Li, Lizhen Wei, Haitao Xiong, Chunhui Wang, Keke Chai, Mengyao Chen, Zhounan Zhu, Tianming Yao, Yun Lin, Chunyan Dong* and Shuo Shi*, Metal-polyphenol-network coated prussian blue nanoparticles for synergistic ferropotosis and apoptosis via triggered GPX4 inhibition and concurrent in situ bleomycin toxification, Small, 2021, 17, 2103919. (IF =15.153)

n 56. Lulu Zhou^#, Jinjin Chen^#, Yunhao Sun, Keke Chai, Zhounan Zhu, Chunhui Wang,  Mengyao Chen, Wenmei Han, Xiaochun Hu, Ruihao Li,  Tianming Yao, Hui Li, Chunyan Dong* and Shuo Shi*, A self-amplified nanocatalytic system for achieving "1+1+1>3" chemodynamic therapy on triple negative breast cancer, Journal of Nanobiotechnology, 2021, 19, 261.

n 55. Mengyao Chen, Chunyan Dong* and Shuo Shi*, Nanoparticle-mediated siRNA delivery and multifunctional modification strategies for effective cancer therapy, Advanced Materials Technology, 2021, 202001236.

n 54. Xiaochun Hu#,Yonglin Lu# , Wenrong Zhao, Menglin Sun, Ruihao Li, Lei Feng, Tianming Yao, Chunyan Dong*, Shuo Shi*, A PDA-DTC/Cu-MnO₂ nanoplatform for MR imaging and multi-therapy of triple-negative breast cancer, Chem. Comm, 2021, 57, 4158-4161.

n 53. Wenrong Zhao^#, Xiaochun Hu^#, Wenhui Li, Ruihao Li, Jinjin Chen, Lulu Zhou, Sufeng Qiang, Shuo Shi*, and Chunyan Dong*, M2-like TAMs function reversal contributes to breast cancer eradication by combination dual immune checkpoint blockade and photothermal Therapy, Small, 2021, 17, 2007051.

n 52. Yanting Sun†, Yuling Li†, Shuo Shi*, and Chunyan Dong*, Exploiting a new approach to destroy the barrier of tumor microenvironment: nano-architecture delivery systems, Molecules 2021, 26(9), 2703.

n 51. Jinjin Chen^#, Lulu Zhou^#, Chunhui Wang, Yunhao Sun, Yonglin Lu, Ruihao Li, Xiaochun Hu, Mengyao Chen, Lv Chen, Tianming Yao, Shuo Shi,* and Chunyan Dong*, Multifunctional SN38-conjugated nanosystem for defeating myelosuppression and diarrhea induced by irinotecan on esophageal cancer, Nanoscale, 2020, 12, 21234-21247.

n 50. Jouharsha Afthab, Nafeesa Khatoon, Lulu Zhou, Tianming Yao, and Shuo Shi*, Hepatoprotective Angelica sinensis silver nanoformulation against multidrug resistant bacteria and the integration of multicomponent logic gate system, Nanoscale, 2020, 12, 19149–19158.

n 49. Chunhui Wang, Jingxian Yang, Chunyan Dong* and Shuo Shi*, Glucose oxidase related cancer therapies, Adv. Therap., 2020, 2000110.

n 48. Xiaochun Hu,# Yonglin Lu,# Lulu Zhou, Lv Chen, Tianming Yao, Liang Shujing, Chunyan Dong,* Shuo Shi*, Post syntheses strategy to integrate porphyrinic metal-organic frameworks with CuS NPs for synergistic enhanced phototherapy, J. Mater. Chem. B, 2020, 8, 935-944.

n 47. Xiaochun Hu, Yonglin Lu, Chunyan Dong, Xuewen Wu, Lulu Zhou, Lv Chen, Tianming Yao*, Shuo Shi*, A Ru(II) polypyridyl alkyne complex based metal−organic frameworks for combined photodynamic/photothermal/chemotherapy, Chem. Eur. J. 2020, 26, 1668 – 1675.

n 46. Lulu Zhou#, Lv Chen#, Xiaochun Hu, Yonglin Lu, Wenjie Liu, Tianming Yao, Chunyan Dong, *and Shuo Shi*, A Cu₉S₅ nanoparticle-based CpG delivery system for synergistic photothermal-, photodynamic- and immunotherapy, Communications Biology, 2020, 3, 343.

n 45. Ruihao Li^#, Yabin Ma^#, Xiaochun Hu, Wenjing Wu, Xuewen Wu, Chunyan Dong, Shuo Shi^*, Yun Lin^*, [Ru(phen)₂podppz]²⁺ significantly inhibits glioblastoma growth in vitro and vivo with fewer side-effects compared with cisplatin, Dalton Trans., 2020, 49, 8864 –8871.

n 44. Jingxian Yang, Chunhui Wang, Shuo Shi*, Chunyan Dong*, Nanotechnologies for enhancing cancer immunotherapy, Nano Research, 2020, 13(10): 2595–2616.

n 43. Wenjie Liu, Xiaochun Hu, Lulu Zhou, Ying Tu, Shuo Shi*, Tian-Ming Yao*, An orientation-inspired perspective on molecular inhibitor of tau aggregation by curcumin conjugated with Ru(II) complex scaffold, J. Phys. Chem. B, 2020, 124, 2343−2353.

n 42. Lv Chen^#, Lulu Zhou^#, Chunhui Wang, Yonglin Lu, Jie Liu, Xiaochun Hu, Tianming Yao, Yun Lin, Shujing Liang, Shuo Shi* and Chunyan Dong*, Tumor-targeted drug and CpG delivery system for phototherapy and docetaxel-enhanced-immunotherapy with polarization toward M1-type macrophages on triple negative breast cancer, Adv. Mater. 2019, 31, 1904997.

n 41. Xiaochun Hu^#, Yonglin Lu^#, Xiaoke Shi, Tianming Yao, Chunyan Dong*, Shuo Shi*, Integrating in situ formation of nanozymes with mesoporous polydopamine for combined chemo, photothermal and hypoxia-overcoming photodynamic therapy, Chem. Commun., 2019, 55, 14785-14788.

n 40. Xiaochun Hu, Zhenli Xu, Jiwen Hu, Chunyan Dong, Yonglin Lu, Xuewen Wu, Maierhaba Wumaier, Tianming Yao*, Shuo Shi*, A redox-activated theranostic nanoplatform: toward glutathione-response imaging guided enhanced photodynamic therapy, Inorg. Chem. Front., 2019, 6, 2865–2872,

n 39. Maierhaba Wumaier, Tian-Ming Yao*, Xiao-Chun Hu, Zhi-An Hu and Shuo Shi*, Luminescent Ru(II)-thiols modified silver nanoparticles for lysosome targeted theranostics, Dalton Trans., 2019, 48, 10393–10397.

n 38. Maierhaba Wumaier, Jing-Jing Shi*, Tian-Ming Yao*, Xiao-Chun Hu, Ru-Ru Gao, Shuo Shi*, G-quadruplex and duplex DNA binding studies of novel ruthenium(II) complexes containing ascididemin ligands, Journal of Inorganic Biochemistry, 2019, 196, 110681.

n 37. Ruimin Zang, Xin Wang, Yanyan Zhu, Tianming Yao, Shuo Shi*, Label-free molecular probe based on G-quadruplex and strand displacement for sensitive and selective detection and naked eye discrimination of Exon 2 Deletion of AIMP2, Chem. Biol. Drug. Des., 2019; 93, 993–998.

n 36. Xiaochun Hu, Danjing Yang, Tianming Yao*, Ruru Gao, Maierhaba Wumaier and Shuo Shi*, Multi-factors (Tail/Loop/Link/Ions) regulation for G-quadruplexes enantioselectivity of Δ- and Λ- [Ru(bpy)₂(dppz-idzo)]²⁺, Dalton Trans., 2018, 47, 5422–5430.

n 35. Ao Huang, Luning Zhang, Weiwei Li, Zeyu Ma, Shuo Shi* and Tianming Yao*, Controlled fluorescence quenching by antibody-conjugated graphene oxide as a mechanism for tau protein sensing, RSOS, 2018, 5, 171808.

n 34. Ru-Ru Gao, Tian-Ming Yao*, Xiao-Yan Lv, Yan-Yan Zhu, Yi-Wei Zhang and Shuo Shi*, Integration of G-quadruplex and DNA-templated Ag NCs for nonarithmetic information processing, Chemical Science, 2017, 8, 4211–4222.

n 33. Ru-Ru Gao, Shuo Shi*, Yu-Jie Li, Maierhaba Wumaier, Xiao-Chun hu and Tian-Ming Yao*, Coordination polymer nanoparticles from nucleotide and lanthanide ions as a versatile platform for color-tunable luminescence and integrating boolean logic operations, Nanoscale, 2017, 9, 9589–9597.

n 32. Ru-Ru Gao, Shuo Shi*, Ying Zhu, Hai-Liang Huang, and Tian-Ming Yao*, A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions, Chemical Science, 2016, 7, 1853-1861.

n 31. Juanjuan Li, Xiaochun Hu, Shuo Shi*, Yiwei Zhang and Tianming Yao*, Three label-free thrombin aptasensors based on aptamers and [Ru(bpy)₂(o-mopip)]²⁺, J. Mater. Chem. B, 2016, 4, 1361–1367.

n 30. Hailiang Huang, Shuo Shi*, Xing Gao, Ruru Gao, Ying Zhu, Xuewen Wu, Ruimin Zang, and Tianming Yao*, A universal label-free fluorescent aptasensor based on Ru complex and quantum dots for adenosine, dopamine and 17 β-estradiol detection, Biosensors and Bioelectronics, 2016, 79, 198–204.

n 29. Ying Zhu, Xiao-chun Hu, Shuo Shi*, Ru-ru Gao, Hai-liang Huang, Yan-yan Zhu, Xiao-yan Lv, Tian-ming Yao*, Ultrasensitive and universal fluorescent aptasensor for the detection of biomolecules (ATP, Adenosine and Thrombin) based on DNA/Ag nanoclusters fluorescence light-up system, Biosensors and Bioelectronics, 2016, 79, 205–212.

n 28. XinWang, Lihong Pei, Xiumin Fan, Shuo Shi*, [Ru(L)₂(3-tppp)]²⁺ (L=bpy, phen) stabilizes two different forms of the human telomeric G-quadruplex DNA, Inorganic Chemistry Communications, 2016, 72, 7–12.

n 27. Shuo Shi*, Xing Gao, Hailiang Huang, Juan Zhao, and Tianming Yao, Effect of the ancillary ligands on the spectral properties and G-quadruplexes DNA binding behaviours: a combined experimental and theoretical study, Chem. Eur.J.2015, 21,13390 –13400.

n 26. Shuo Shi*, Jin-Hong Xu, Xing Gao, Hai-Liang Huang and Tian-Ming Yao*, Binding behaviours for different types of DNA G-quadruplexes: enantiomers of [Ru(bpy)₂(L)]²⁺ (L= dppz, dppz-idzo), Chem. Eur. J. 2015, 21, 11435 – 11445.

n 25. Hailiang Huang, Shuo Shi*, Xuyue Zheng, Tianming Yao*, Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification, Biosensors and Bioelectronics, 2015, 71, 439–444.

n 24. Xuyue Zheng, Tianming Yao*, Ying Zhu and Shuo Shi*, Cu²⁺ Modulated silver nanoclusters as an On-Off-On fluorescence probe for the selective detection of L-histidine, Biosensors and Bioelectronics, 2015,66, 103–108.

n 23. Xing Gao, Shuo Shi*, Jun-Liang Yao, Juan Zhao and Tian-Ming Yao*, Impacts of terminal modification of [Ru(phen)₂dppz]²⁺ on the luminescence properties: a theoretical study, Dalton Trans., 2015, 44, 19264–19274.

n 22. Xiao-Hui Lu, Shuo Shi*, Jun-Liang Yao, Xing Gao, Hai-Liang Huang, Tian-Ming Yao*, Two structurally analogous ruthenium complexes as naked-eye and reversible molecular “light switch” for G-quadruplex DNA, Journal of Inorganic Biochemistry, 2014, 140, 64-71.

n 21. Linlin Wang, Tianming Yao*, Shuo Shi*, Yanlin Cao, Wenliang Sun A label-free fluorescent probe for Hg²⁺ and biothiols based on graphene oxide and Ru-complex, Scientific Reports, 2014, 4, 5320.

n 20. Yanlin Cao, Shuo Shi*, Linlin Wang, Junliang Yao and Tianming Yao*, Ultrasensitive fluorescence detection of heparin based on quantum dots and a functional ruthenium polypyridyl complex, Biosensors and Bioelectronics, 2014, 55, 174-179.

n 19. Shuo Shi*‡, Shane Gao,‡ Tongcheng Cao, Jie liu, Xing Gao, Jian Hao, Chunyan Lv, Hailiang Huang, Jun Xu*, Tianming Yao*, Targeting human telomeric G-quadruplex DNA and inhibition of telomerase activity with [(dmb)₂Ru(obip)Ru(dmb)₂]⁴⁺, PloS ONE, 2013, 8(12), e84419.

n 18. Shuo Shi*, Xin Wang, Wenliang Sun, Xiangyang Wang, Tianming Yao*, Liangnian Ji, Label-free fluorescent DNA biosensors based on metallointercalators and nanomaterials, Methods, 2013, 64, 305-314.

n 17. Shuo Shi*, Hai-Liang Huang, Xing Gao, Jun-Liang Yao,Chun-Yan Lv, Juan Zhao, Wen-Liang Sun, Tian-Ming Yao*, Liang-Nian Ji，A comparative study of the interaction of two structurally analogous ruthenium complexes with human telomeric G-quadruplex DNA, Journal of Inorganic Biochemistry, 2013,121,19-27.

n 16. Junliang Yao, Xing Gao, Wenliang Sun, Tianming Yao*, Shuo Shi*, and Liangnian Ji, Molecular hairpin: a possible model for inhibition of tau aggregation by tannic acid, Biochemistry 2013, 52, 1893−1902.

n 15. Wenliang Sun, Junliang Yao, Tianming Yao* and Shuo Shi*, Label-free fluorescent DNA sensor for the detection of silver ions based on molecular light switch Ru complex and unmodified quantum dots, Analyst, 2013,138, 421-424.

n 14. Jun-Liang Yao, Xing Gao, Wenliang Sun, Shuo Shi* and Tian-Ming Yao*, [Ru(bpy)₂dppz-idzo]²⁺: A colorimetric molecular “light switch” and powerful stabilizer for G-quadruplex DNA, Dalton Trans., 2013, 42, 5661–5672.

n 13. Shuo Shi*, Juan Zhao, Xing Gao, Chunyan Lv, Li Yang, Jian Hao, Hailiang Huang, Junliang Yao, Wenliang Sun, Tianming Yao*, and Liangnian Ji, Molecular “light switch” for G-quadruplexes DNA: cycling the switch on and off, Dalton Trans, 2012., 41, 5789–5793.

n 12. Shuo Shi *, Chunyan Lv, Xing Gao, Juan Zhao, Junliang Yao, Wenliang Sun, Hailing Huang, Tianming Yao*, Liangnian Ji, [Ru(bpy)₂(bppp)]²⁺ binds two different forms of the human telomeric G-quadruplex structure, Inorganic Chemistry Communications, 2012, 24, 212–215.

n 11. Yao Junliang, Gao Xing, Sun Wenliang, Fan Xuezhong, Shi Shuo*, Yao Tianming*, A naked-eye on–off–on molecular “light switch” based on a reversible “conformational switch” of G-quadruplex DNA, Inorg. Chem., 2012,51, 12591-12593.

n 10. Wenliang Sun, Tianming Yao* and Shuo Shi*, A molecular light switch Ru complex and quantum dots for the label-free, aptamer-based detection of thrombin, Analyst, 2012, 137, 1550–1552.

n 9. Dan-Jing Yang, Shuo Shi*, Tian-Ming Yao*, Liang-Nian Ji, Cooperative folding of tau peptide by coordination of group IIB metal cations during heparin-induced aggregation, Biometals, 2012, 25,361–372.

n 8. Shuo Shi*, Juan Zhao, Xiaoting Geng, Tianming Yao*, Hailiang Huang, Tianlin Liu, Lengfeng Zheng, Zonghui Li, Danjing Yang, and Liangnian Ji, Molecular “light switch” for G-quadruplexes and i-motif of human telomeric DNA: [Ru(phen)₂(dppz)]²⁺, Dalton Trans, 2010, 39，2490-2493.

n 7. Shuo Shi *, Xiaoting Geng, Juan. Zhao, Tianming Yao*, Chaoran Wang, Danjing Yang, Lengfeng Zheng, Liangnian Ji, Interaction of [Ru(bpy)₂(dppz)]²⁺ with human telomeric DNA: preferential binding to G-quadruplexes over i-motif, Biochimie, 2010, 92, 370-377.

n 6. Shuo Shi*, Tian-ming Yao, Xiao-ting Geng, Ling-feng Jiang, Jie Liu, Qing-yuan Yang, and Liangnian Ji*, Synthesis, characterization and DNA-binding of chiral complexes D- and L- [Ru(bpy)₂(pyip)]²⁺, Chirality, 2009, 21, 276-283.

n 5. Shuo Shi*, Tian Xie, Tian-Ming Yao*, Chao-Ran Wang, Xiao-Ting Geng, Dan-Jing Yang, Lin-Jie Han, Liang-Nian Ji, Synthesis, characterization, DNA-binding and DNA-photocleavage studies of [Ru(bpy)₂(pmip)]²⁺ and [Ru(phen)₂(pmip)]²⁺ (pmip = 2-(2′-pyrimidyl)imidazo[4,5-f][1,10]phenanthroline, Polyhedron, 2009,18, 1355–1361.

n 4. Shuo Shi, Jie Liu*, Tianming Yao, Xiaoting Geng, Lingfeng Jiang, Qingyuan Yang, Lin Cheng, and Liangnian Ji*, Promoting the formation and stabilization of G-quadruplex by dinuclear Ru^II complex Ru₂(obip)L₄, Inorganic Chemistry, 2008, 47 (8), 2910-2912.

n 3. Shuo Shi, Cai-Ping Tan, Jie Liu, and Liang-Nian Ji*, Conformation conversion and stabilization of G-quadruplex by dinuclear Ru^II complex [(bpy)₂Ru(obip)Ru(bpy)₂]⁴⁺, Journal of Biomolecular Structure Dynamics, 2007, 24, 706.

n 2. Shuo Shi, Jie Liu*, Jun Li, Kang-Cheng Zheng, Xiao-Mei Huang, Cai-Ping Tan, Lan-Mei Chen and Liang-Nian Ji*, Synthesis, characterization and DNA-binding of novel chiral complexes D- and L- [Ru(bpy)₂L]²⁺ (L= o-mopip and p-mopip), Journal of Inorganic Biochemistry, 100 (2006) 385–395.

n 1. Shuo Shi, Jie Liu*, Jun Li, Kang C. Zheng, Cai P. Tan, Lan M. Chen and Liang N. Ji*, Electronic effect of different positions of the –NO₂ group on the DNA-intercalator of chiral complexes [Ru(bpy)₂L]²⁺ (L = o-npip, m-npip and p-npip), Dalton Trans., 2005, 2038– 2046.

热忱欢迎具有化学，生命科学，药学，医学，材料学, 环境科学等背景的同学报考本课题组的研究生，欢迎具有以上背景的博士到课题组开展博士后研究工作，欢迎本科生到本实验室开展毕业论文及SITP项目工作。