个人介绍

同济大学特聘研究员，青年百人B岗。2020年博士毕业于复旦大学，导师：张凡教授。随后进入新加坡国立大学从事博士后研究工作。2026年7月以高层次人才引进加入同济大学化学科学与工程学院。聚焦近红外二区有机分子探针设计及活体成像及传感分析。已发表44篇SCI论文，其中第一/通讯（含共同）作者共发表18篇，包括Nat. Nanotechnol.、J. Am. Chem. Soc.（2篇）、Angew. Chem. Int. Ed.（4篇）、Nat. Commun.（2篇）、Adv. Mater.（2篇）等，其中5篇论文入选ESI高被引论文，9篇他引超过100次，单篇最高被引606次。Web of Science总引用4500余次，H因子为32，已授权发明专利4项。

一、研究方向

1. 近红外二区活体成像与生化分析

2. 新型近红外二区分子探针设计开发

3. 活体核酸分析

4. 核酸递送体系开发

二、近五年代表论文（#共同第一作者，*通讯作者）

1. B. Yang#, B. Li#, Y. Zhu*, M. Zhao, Y. Cheng, X. Zhao, E. Deryn Teoh, Y. Wang, M. Zhang, X. Tang, S. Jin, Y. Sun, X. Zhang, B. Xue, J. Yan, G. Wu, Z. Lin, M. Luo, H. Yu, L. Zhang, X. Chen*, Q. Ni* Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production. Nat. Nanotechnol., 2026, 21, 407-418.

2. B. Li, J. Wang*, Y. Peng, C. Liu, Y. Ming, B. Yang, D. He, W. Lai, L. Guo, M. Zhao*, X. Chen* BODIPY-Doped Nanocarrier Engineering (BONE) Improves Bone Marrow mRNA Delivery by NIR-II Bioimaging Guided Screening. J. Am. Chem. Soc., 2026, 148, 4966-4975.

3. B.Li#, M. Zhao#*, B. Yang, T. Yang, Y. Wang, Y. Hu, M. Zhang, J. Ge, X. Tang, Z. Zhang, H. Cui, X. Chen, Y. Y. Yang, L. Peng, Q. Ni* Antioxidant Lipid Nanoparticles Enhance mRNA Stability for Regeneration Therapy and Gene Editing. Nat. Commun., 2026, DOI:10.1038/s41467-026-73512-3.

4. F. Zhai#, B. Yun#, J. Ming, T. Yu, B. Li*, X. Liu, X. Wang, Z. Chen, C. Song, M. Zhao, W. Li, Z. Liu, A. Liang*, J. Li*, F. Zhang* Non-Invasive Diagnosis of Early Colorectal Cancerization via Amplified Sensing of MicroRNA-21 in NIR-II Window. Adv. Mater., 2025, 37, 2501378.

5. B. Li#, H. Liu#, M. Zhao, X. Zhang, P. Huang, X. Chen*, J. Lin* Carboxylesterase Activatable Molecular Probe for Personalized Treatment Guidance by Analyte-Induced Molecular Transformation. Angew. Chem. Int. Ed., 2024, 63, e202404093.

6. B. Li#, M. Zhao#, W. Lai, X. Zhang, B. Yang, X. Chen*, Q. Ni* Activatable NIR-II Photothermal Lipid Nanoparticles for Improved Messenger RNA Delivery. Angew. Chem. Int. Ed., 2023, e202302676.

7. B. Li, H. Liu, Y. He, M. Zhao, C. Ge, M. R. Younis, P. Huang*, X. Chen*, J. Lin* A "Self-Checking" pH/Viscosity-Activatable NIR-II Molecule for Real-Time Evaluation of Photothermal Therapy Efficacy. Angew. Chem. Int. Ed., 2022, 61, e202200025.

8. B. Li#, M. Zhao#, J. Lin, P. Huang*, X. Chen* Management of Fluorescent Organic/inorganic Nanohybrids for Biomedical Applications in the NIR-II Region. Chem. Soc. Rev., 2022, 51, 7692.

热诚欢迎有志于从事探针开发、活体成像及传感、核酸分析及递送等前沿领域的科研助理、本科生、研究生及博士后加入本课题组！